Antibiotic susceptibility test (AST)

Definition:

Antibiotic susceptibility test (AST) is the measurement of the susceptibility of bacteria to antibiotics.ASThas been needed since the discovery of the beta-lactam antibiotic penicillin. The test results can allow a clinician to change the choice of antibiotics from empiric therapy, which is when an antibiotic is selected based on clinical suspicion about the site of an infection and common causative bacteria, to directed therapy, in which the choice of antibiotic is based on knowledge of the organism and its sensitivities.

References:

[1]. Leekha S, et al. General principles of antimicrobial therapy. Mayo Clin Proc. 2011 Feb;86(2):156-67. [Content Brief]

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