Antileukoproteinase

Definition:

Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells.

References:

[1]. Kei Fukushima, et al. Structure basis 1/2SLPI and porcine pancreas trypsin interaction. J Synchrotron Radiat. 2013 Nov;20(Pt 6):943-7. [Content Brief]

[2]. M S Mulligan, et al. Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor. Am J Pathol. 2000 Mar;156(3):1033-9. [Content Brief]

[3]. R Heinzel, et al. Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus. Eur J Biochem. 1986 Oct 1;160(1):61-7. [Content Brief]

[4]. S P Eisenberg, et al. Location of the protease-inhibitory region of secretory leukocyte protease inhibitor. J Biol Chem. 1990 May 15;265(14):7976-81. [Content Brief]

[5]. Olga Klimenkova, et al. A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood. 2014 Feb 20;123(8):1239-49. [Content Brief]

[6]. J M Sallenave, et al. Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor. Biol Chem Hoppe Seyler. 1991 Jan;372(1):13-21. [Content Brief]

[7]. R C Thompson, et al. Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6692-6. [Content Brief]

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