AP-5 complex subunit sigma-1

Definition:

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair.

References:

[1]. Jennifer Hirst, et al. The fifth adaptor protein complex. PLoS Biol. 2011 Oct;9(10):e1001170. [Content Brief]

[2]. Mikołaj Słabicki, et al. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. PLoS Biol. 2010 Jun 29;8(6):e1000408. [Content Brief]

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