Apolipoprotein A-V

Definition:

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin.

References:

[1]. L A Pennacchio, et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science. 2001 Oct 5;294(5540):169-73. [Content Brief]

[2]. Stefan K Nilsson, et al. Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Biochemistry. 2007 Mar 27;46(12):3896-904. [Content Brief]

[3]. Jennifer A Beckstead, et al. Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis. Biochemistry. 2003 Aug 12;42(31):9416-23. [Content Brief]

[4]. Peter J O'Brien, et al. The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins. Clin Chem. 2005 Feb;51(2):351-9. [Content Brief]

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