Apoptosis-enhancing nuclease

Definition:

Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.

References:

[1]. T Kawase, et al. p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis. Oncogene. 2008 Jun 19;27(27):3797-810. [Content Brief]

[2]. Ji-Hyun Lee, et al. Identification of a novel ionizing radiation-induced nuclease, AEN, and its functional characterization in apoptosis. Biochem Biophys Res Commun. 2005 Nov 11;337(1):39-47. [Content Brief]

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