Aquaporin-10

Definition:

[Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH. The channel is permeable to glycerol, especially when the cytosolic pH is acidified. Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation. May contribute to water transport in the intestine (Probable).; [Isoform 2]: Water channel that mediates water transport across cell membranes, but that is not permeable to glycerol.

References:

[1]. Kamil Gotfryd, et al. Human adipose glycerol flux is regulated by a pH gate in AQP10. Nat Commun. 2018 Nov 12;9(1):4749. [Content Brief]

[2]. Fredrik Öberg, et al. Glycosylation increases the thermostability of human aquaporin 10 protein. J Biol Chem. 2011 Sep 9;286(36):31915-23. [Content Brief]

[3]. Umberto Laforenza, et al. Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes. PLoS One. 2013;8(1):e54474. [Content Brief]

[4]. S Hatakeyama, et al. Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum. Biochem Biophys Res Commun. 2001 Oct 5;287(4):814-9. [Content Brief]

[5]. Kenichi Ishibashi, et al. Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin. Biochim Biophys Acta. 2002 Jul 19;1576(3):335-40. [Content Brief]

[6]. A Mobasheri, et al. Immunohistochemical localization of aquaporin 10 in the apical membranes of the human ileum: a potential pathway for luminal water and small solute absorption. Histochem Cell Biol. 2004 Jun;121(6):463-71. [Content Brief]

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