Aquaporin-3

Definition:

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).

References:

[1]. Kamil Gotfryd, et al. Human adipose glycerol flux is regulated by a pH gate in AQP10. Nat Commun. 2018 Nov 12;9(1):4749. [Content Brief]

[2]. Nathalie Roudier, et al. AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL. J Biol Chem. 2002 Nov 29;277(48):45854-9. [Content Brief]

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