Aquaporin-5

Definition:

Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity).

References:

[1]. Rob Horsefield, et al. High-resolution x-ray structure of human aquaporin 5. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13327-32. [Content Brief]

[2]. M D Lee, et al. The human Aquaporin-5 gene. Molecular characterization and chromosomal localization. J Biol Chem. 1996 Apr 12;271(15):8599-604. [Content Brief]

[3]. Xibao Liu, et al. A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem. 2006 Jun 2;281(22):15485-95. [Content Brief]

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