Arginine-glutamic acid dipeptide repeats protein

Definition:

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.

References:

[1]. T Waerner, et al. Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis. Cell Growth Differ. 2001 Apr;12(4):201-10. [Content Brief]

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