Arrestin domain-containing protein 1

Definition:

Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles. By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway.

References:

[1]. KimberlyD Mackenzie, et al. Regulation of the divalent metal ion transporter via membrane budding. Cell Discov. 2016 Jun 21;2:16011. [Content Brief]

[2]. Loredana Puca, et al. Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals. J Cell Sci. 2013 Oct 1;126(Pt 19):4457-68. [Content Brief]

[3]. Joseph F Nabhan, et al. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4146-51. [Content Brief]

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