Asperger syndrome

Definition:

Asperger syndrome (AS), a behavioral disorder that is related to autism, is associated with abnormal social functioning and repetitive behaviors but not with a decrease in intelligence or linguistic functionality. AS may be present with several comorbid disorders including attention deficit hyperactivity disorder, anxiety, schizophrenia, bipolar disorder, depression, and Tourette syndrome. The standard pharmacotherapies typically administered to other comorbid disorders are also prescribed to AS patients. Although medication therapy may be beneficial in stabilizing AS patients, it does not cure the disorder. Cognitive behavioural therapy (CBT) may be an effective behavioral approach to implement, and it may also reduce the number of pharmacotherapies necessary for AS patients. The pathophysiology of AS remains unclear and the causes of AS are not known. The male-to-female ratio is 8:1 in AS. Genetic factors appear to play a role in AS because of their tendency to run in families and the high concordance in twins. However, a specific gene for AS has not been identified. Recent studies have suggested that the mutations in two X-linked genes, neuroligins NLGN3 and NLGN4 are associated with autism and AS.

References:

[1]. C Gillberg, et al. The Asperger Syndrome (and high-functioning autism) Diagnostic Interview (ASDI): a preliminary study of a new structured clinical interview. Autism. 2001 Mar;5(1):57-66. [Content Brief]

[2]. F I Tarazi, et al. Asperger's syndrome: diagnosis, comorbidity and therapy. Expert Rev Neurother. 2015 Mar;15(3):281-93. [Content Brief]

[3]. Stéphane Jamain, et al. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat Genet. 2003 May;34(1):27-9. [Content Brief]

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