ATM interactor

Definition:

Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.

References:

[1]. Nnennaya Kanu, et al. ATMIN defines an NBS1-independent pathway of ATM signalling. EMBO J. 2007 Jun 20;26(12):2933-41. [Content Brief]

[2]. Carolyn J McNees, et al. ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage. EMBO J. 2005 Jul 6;24(13):2447-57. [Content Brief]

[3]. Sabine Jurado, et al. ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression. J Biol Chem. 2012 Jan 27;287(5):3156-64. [Content Brief]

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