ATP-binding cassette sub-family G member 4

Definition:

ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells.

References:

[1]. Zoltán Hegyi, et al. Functional Cooperativity between ABCG4 and ABCG1 Isoforms. PLoS One. 2016 May 26;11(5):e0156516. [Content Brief]

[2]. Alryel Yang, et al. Regulation of ABCG4 transporter expression by sterols and LXR ligands. Biochim Biophys Acta Gen Subj. 2021 Jan;1865(1):129769. [Content Brief]

[3]. Judit Cserepes, et al. Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization. Biochem Biophys Res Commun. 2004 Jul 30;320(3):860-7. [Content Brief]

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