ATP-dependent RNA helicase DHX29

Definition:

ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

References:

[1]. Yaser Hashem, et al. Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. Cell. 2013 May 23;153(5):1108-19. [Content Brief]

[2]. Vera P Pisareva, et al. Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29. Cell. 2008 Dec 26;135(7):1237-50. [Content Brief]

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