ATPase GET3

Definition:

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling.

References:

[1]. Vincenzo Favaloro, et al. Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins. J Cell Sci. 2008 Jun 1;121(11):1832-40. [Content Brief]

[2]. Jee-Young Mock, et al. Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):106-11. [Content Brief]

[3]. Sandra Stefanovic, et al. Identification of a targeting factor for posttranslational membrane protein insertion into the ER. Cell. 2007 Mar 23;128(6):1147-59. [Content Brief]

[4]. Yasunori Yamamoto, et al. Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells. Mol Cell. 2012 Nov 9;48(3):387-97. [Content Brief]

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