Aurora kinase A and ninein-interacting protein

Definition:

DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.

References:

[1]. Jiangman Lou, et al. AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway. Nat Commun. 2017 Oct 17;8(1):985. [Content Brief]

[2]. Ann-Shung Lieu, et al. Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation. Int J Oncol. 2010 Aug;37(2):429-36. [Content Brief]

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