Base excision repair (BER)

Definition:

Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens.

References:

[1]. Grigory L Dianov, et al. Mammalian base excision repair: the forgotten archangel. Nucleic Acids Res. 2013 Apr 1;41(6):3483-90. [Content Brief]

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