Beta,beta-carotene 15,15'-dioxygenase

Definition:

Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.

References:

[1]. Carlo dela Seña, et al. The human enzyme that converts dietary provitamin A carotenoids to vitamin A is a dioxygenase. J Biol Chem. 2014 May 9;289(19):13661-6. [Content Brief]

[2]. W Yan, et al. Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics. 2001 Mar 1;72(2):193-202. [Content Brief]

[3]. Annika Lindqvist, et al. Loss-of-function mutation in carotenoid 15,15'-monooxygenase identified in a patient with hypercarotenemia and hypovitaminosis A. J Nutr. 2007 Nov;137(11):2346-50. [Content Brief]

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