Burkitt lymphoma

Definition:

Burkitt lymphoma (BL) is a highly aggressive mature B-cell non-Hodgkin's lymphoma consisting of endemic, sporadic, and immunodeficiency-associated variants. Endemic BL (eBL) affects children and young adults in Africa and some other geographical areas and carries Epstein-Barr virus (EBV) in more than 95% of cases. In contrast, sporadic BL (sBL) among adolescents in Europe and North America are mostly EBV-negative. A third type of BL is associated with HIV-infection in adults. All of these subtypes possess chromosomal rearrangements of the c-myc oncogene, the genetic hallmark of BL that contributes to lymphomagenesis through alterations in cell cycle regulation, cellular differentiation, apoptosis, cellular adhesion, and metabolism. Many BL carry point mutation in the p53 tumor suppressor gene or other defects in the p14ARF-MDM2-p53 pathway, and inactivation of the p16INK4a gene by promoter methylation or homozygous deletion. This indicates that disruption of both the pRb and p53 tumor suppressor pathways is critical for BL development.

References:

[1]. Ada Kolman, et al. Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990-2001). Mutat Res. 2002 Dec;512(2-3):173-94. [Content Brief]

[2]. Andreas Luch, et al. Nature and nurture - lessons from chemical carcinogenesis. Nat Rev Cancer. 2005 Feb;5(2):113-25. [Content Brief]

[3]. Christian C Abnet, et al. Carcinogenic food contaminants. Cancer Invest. 2007 Apr-May;25(3):189-96. [Content Brief]

[4]. David Schottenfeld, et al. Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions. Annu Rev Public Health. 2005;26:37-60. [Content Brief]

[5]. Mikael S Lindström, et al. Role of genetic and epigenetic changes in Burkitt lymphoma. Semin Cancer Biol. 2002 Oct;12(5):381-7. [Content Brief]

[6]. Purvi Patel, et al. Azathioprine induced hodgkin lymphoma: a case report and review of literature. Am J Clin Oncol. 2005 Aug;28(4):427-8. [Content Brief]

[7]. Ralf Küppers, et al. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer. 2005 Apr;5(4):251-62. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.