C-type lectin domain family 12 member B

Definition:

Inhibitory receptor postulated to negatively regulate immune and non-immune functions. Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals. Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart. May limit activation of myeloid cell subsets in response to infection or tissue inflammation. May protect target cells against natural killer cell-mediated lysis. May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3.

References:

[1]. Sabrina C Hoffmann, et al. Identification of CLEC12B, an inhibitory receptor on myeloid cells. J Biol Chem. 2007 Aug 3;282(31):22370-5. [Content Brief]

[2]. Henri Montaudié, et al. CLEC12B Decreases Melanoma Proliferation by Repressing Signal Transducer and Activator of Transcription 3. J Invest Dermatol. 2022 Feb;142(2):425-434. [Content Brief]

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