C-type lectin domain family 2 member D

Definition:

Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.

References:

[1]. Christine T Gange, et al. Characterization of sugar binding by osteoclast inhibitory lectin. J Biol Chem. 2004 Jul 9;279(28):29043-9. [Content Brief]

[2]. Claire Germain, et al. Characterization of alternatively spliced transcript variants of CLEC2D gene. J Biol Chem. 2010 Nov 12;285(46):36207-15. [Content Brief]

[3]. Porunelloor A Mathew, et al. The LLT1 receptor induces IFN-gamma production by human natural killer cells. Mol Immunol. 2004 Mar;40(16):1157-63. [Content Brief]

[4]. David B Rosen, et al. Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. J Immunol. 2005 Dec 15;175(12):7796-9. [Content Brief]

[5]. Yun Shan Hu, et al. Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts. J Bone Miner Res. 2004 Jan;19(1):89-99. [Content Brief]

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