C-X-C motif chemokine 17

Definition:

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.; [4-Cys CXCL17]: Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.

References:

[1]. Edward J Weinstein, et al. VCC-1, a novel chemokine, promotes tumor growth. Biochem Biophys Res Commun. 2006 Nov 10;350(1):74-81. [Content Brief]

[2]. Carl-Fredrik Flach, et al. Broad up-regulation of innate defense factors during acute cholera. Infect Immun. 2007 May;75(5):2343-50. [Content Brief]

[3]. José L Maravillas-Montero, et al. Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17. J Immunol. 2015 Jan 1;194(1):29-33. [Content Brief]

[4]. Wei-Yu Lee, et al. CXCL17, an orphan chemokine, acts as a novel angiogenic and anti-inflammatory factor. Am J Physiol Endocrinol Metab. 2013 Jan 1;304(1):E32-40. [Content Brief]

[5]. M Teresa Pisabarro, et al. Cutting edge: novel human dendritic cell- and monocyte-attracting chemokine-like protein identified by fold recognition methods. J Immunol. 2006 Feb 15;176(4):2069-73. [Content Brief]

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