Calpain-1 catalytic subunit

Definition:

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. Cleaves and activates caspase-7 (CASP7).

References:

[1]. Juliette Gafni, et al. Calpain-1 cleaves and activates caspase-7. J Biol Chem. 2009 Sep 11;284(37):25441-9. [Content Brief]

[2]. H Sorimachi, et al. A novel member of the calcium-dependent cysteine protease family. Biol Chem Hoppe Seyler. 1990 May;371 Suppl:171-6. [Content Brief]

[3]. Chiung-Yueh Hsu, et al. Deimination of human filaggrin-2 promotes its proteolysis by calpain 1. J Biol Chem. 2011 Jul 1;286(26):23222-33. [Content Brief]

[4]. Yasuko Ono, et al. PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1. J Mol Biol. 2013 Aug 23;425(16):2955-72. [Content Brief]

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