Calpains

Definition:

Calpains are a group of non-lysosomal Ca²⁺-dependent cysteine proteases with numerous substrates. Calpains have been identified in almost all eukaryotes and bacteria.In the human genome, this group of enzymes has 15 isoforms and is present ubiquitously and demonstrates tissue-specific patterns of expression. Calpains are involved in different physiological and pathological processes such as cell proliferation, migration, invasion, apoptosis and signal transduction and their roles in various disorders have been reported.

References:

[1]. Hosseini M, et al. Calpains: Diverse Functions but Enigmatic. Arch Iran Med. 2018 Apr 1;21(4):170-179. [Content Brief]

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