Candidiasis

Definition:

Candidiasis is a fungal infection with Candida species, predominantly with Candida albicans. Invasive candidiasis is a major cause of morbidity and mortality in the intensive care unit (ICU) setting, causing bloodstream infections. Recently, various non-C. albicans species have emerged as infecting agents. In patients with impaired IL-17 immunity, recurrent or persistent infections are observed (chronic mucocutaneous candidiasis disease).

References:

[1]. Anne Puel, et al. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science. 2011 Apr 1;332(6025):65-8. [Content Brief]

[2]. C Rodloff, et al. Epidemiology and antifungal resistance in invasive candidiasis. Eur J Med Res. 2011 Apr 28;16(4):187-95. [Content Brief]

[3]. Luyan Liu, et al. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med. 2011 Aug 1;208(8):1635-48. [Content Brief]

[4]. Marie Méan, et al. Bench-to-bedside review: Candida infections in the intensive care unit. Crit Care. 2008;12(1):204. [Content Brief]

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