CD48 antigen

Definition:

Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells.

References:

[1]. Arshad Muhammad, et al. Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome. J Immunol. 2009 Jun 15;182(12):7672-80. [Content Brief]

[2]. Maren Claus, et al. Modulation of natural killer cell functions by interactions between 2B4 and CD48 in cis and in trans. Open Biol. 2016 May;6(5):160010. [Content Brief]

[3]. M H Brown, et al. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. J Exp Med. 1998 Dec 7;188(11):2083-90. [Content Brief]

[4]. Ibrahim Y Hawash, et al. The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling. Biochim Biophys Acta. 2002 Apr 3;1589(2):140-50. [Content Brief]

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