CDC42 small effector protein 1

Definition:

Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.

References:

[1]. D M Pirone, et al. SPECs, small binding proteins for Cdc42. J Biol Chem. 2000 Jul 28;275(30):22650-6. [Content Brief]

[2]. Kathryn H Ching, et al. Biochemical characterization of distinct regions of SPEC molecules and their role in phagocytosis. Exp Cell Res. 2007 Jan 1;313(1):10-21. [Content Brief]

[3]. Kathryn H Ching, et al. The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse. J Biol Chem. 2005 Jun 24;280(25):23660-7. [Content Brief]

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