Cementoblastoma-derived protein 1

Definition:

May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum. Binds hydroxyapatite and may promote the biomineralization of the cementum. Also promotes cell proliferation.

References:

[1]. Mercedes Bermúdez, et al. CEMP1 Induces Transformation in Human Gingival Fibroblasts. PLoS One. 2015 May 26;10(5):e0127286. [Content Brief]

[2]. Lía Hoz, et al. Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions. Cell Biol Int. 2012 Feb;36(2):129-36. [Content Brief]

[3]. Bruno Carmona-Rodríguez, et al. Human Cementum Protein 1 induces expression of bone and cementum proteins by human gingival fibroblasts. Biochem Biophys Res Commun. 2007 Jul 6;358(3):763-9. [Content Brief]

[4]. Eduardo Villarreal-Ramírez, et al. Characterization of recombinant human cementum protein 1 (hrCEMP1): primary role in biomineralization. Biochem Biophys Res Commun. 2009 Jun 19;384(1):49-54. [Content Brief]

[5]. Motohiro Komaki, et al. Cementum protein 1 (CEMP1) induces a cementoblastic phenotype and reduces osteoblastic differentiation in periodontal ligament cells. J Cell Physiol. 2012 Feb;227(2):649-57. [Content Brief]

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