Centrosomal protein of 120 kDa

Definition:

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.

References:

[1]. Ching-Wen Chang, et al. CEP295 interacts with microtubules and is required for centriole elongation. J Cell Sci. 2016 Jul 1;129(13):2501-13. [Content Brief]

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