Cilia- and flagella-associated protein 91

Definition:

Involved in sperm flagellum axonemal organization and function. May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).

References:

[1]. Hiroshi Yukitake, et al. AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase. J Biol Chem. 2002 Nov 22;277(47):45480-92. [Content Brief]

[2]. Guillaume Martinez, et al. Biallelic variants in MAATS1 encoding CFAP91, a calmodulin-associated and spoke-associated complex protein, cause severe astheno-teratozoospermia and male infertility. J Med Genet. 2020 Oct;57(10):708-716. [Content Brief]

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