Colonystimulating factor 1 (CSF1)

Definition:

Colony-stimulating factor-1 (CSF-1), also known as macrophage colony-stimulating factor, controls the survival, proliferation, and differentiation of mononuclear phagocytes and regulates cells of the females reproductive tract. The effects of CSF-1 are mediated by a high-affinity receptor tyrosine kinase (CSF-1R)3-5 encoded by the c-fms protooncogene. CSF-1appears to play an autocrine and/or paracrine role in cancers of the ovary, endometrium, breast, and myeloid and lymphoid tissues.

References:

[1]. E R Stanley, et al. Biology and action of colony--stimulating factor-1. Mol Reprod Dev. 1997 Jan;46(1):4-10. [Content Brief]

[2]. G R Ryan, et al. Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis. Blood. 2001 Jul 1;98(1):74-84. [Content Brief]

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