Complement factor H-related protein 2

Definition:

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.

References:

[1]. Elena Goicoechea de Jorge, et al. Dimerization of complement factor H-related proteins modulates complement activation in vivo. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4685-90. [Content Brief]

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