Congenital hyperthyroidism

Definition:

Congenital hyperthyroidism is a rare clinical condition, and in most cases, it is a transient disorder caused by maternal Graves disease associated with the transplacental passage of maternal thyroid-stimulating antibodies. Germline mutations of thyrotropin receptor (TSHR) gene determining a constitutive activation of the receptor were identified as a molecular cause of congenital nonautoimmune hyperthyroidism. TSHR gene mutations also cause the familial gestational hyperthyroidism, that is characterized by thyrotoxicosis and hyperemesis gravidarum.

References:

[1]. Angela M Leung, et al. Perchlorate, iodine and the thyroid. Best Pract Res Clin Endocrinol Metab. 2010 Feb;24(1):133-41. [Content Brief]

[2]. C Asteria, et al. TSH receptor gene mutations and familial gestational hyperthyroidism. Eur J Endocrinol. 1999 Aug;141(2):93-4. [Content Brief]

[3]. Patrizia Agretti, et al. Sporadic congenital nonautoimmune hyperthyroidism caused by P639S mutation in thyrotropin receptor gene. Eur J Pediatr. 2012 Jul;171(7):1133-7. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.