Cytoplasmic dynein 2 intermediate chain 2

Definition:

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis. Required also to maintain a functional transition zone.; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.

References:

[1]. David Asante, et al. Subunit composition of the human cytoplasmic dynein-2 complex. J Cell Sci. 2014 Nov 1;127(Pt 21):4774-87. [Content Brief]

[2]. Laura Vuolo, et al. Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function. Elife. 2018 Oct 16;7:e39655. [Content Brief]

[3]. Dong Gao, et al. WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. Cell Mol Life Sci. 2009 Aug;66(15):2573-84. [Content Brief]

[4]. Yuta Tsurumi, et al. Interactions of the dynein-2 intermediate chain WDR34 with the light chains are required for ciliary retrograde protein trafficking. Mol Biol Cell. 2019 Mar 1;30(5):658-670. [Content Brief]

[5]. Yuki Hamada, et al. Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking. Mol Biol Cell. 2018 Jul 1;29(13):1628-1639. [Content Brief]

[6]. Céline Huber, et al. WDR34 mutations that cause short-rib polydactyly syndrome type III/severe asphyxiating thoracic dysplasia reveal a role for the NF-κB pathway in cilia. Am J Hum Genet. 2013 Nov 7;93(5):926-31. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.