DCN1-like protein 3

Definition:

Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation.

References:

[1]. Matthew J Keuss, et al. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. J Cell Sci. 2016 Apr 1;129(7):1441-54. [Content Brief]

[2]. Teng Ma, et al. DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth. Cancer Sci. 2008 Nov;99(11):2128-35. [Content Brief]

[3]. Guochang Huang, et al. SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1). J Biol Chem. 2014 Dec 12;289(50):34728-42. [Content Brief]

[4]. Shuai Zhang, et al. DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage. Oncotarget. 2016 Sep 6;7(36):58483-58491. [Content Brief]

[5]. Nathalie Meyer-Schaller, et al. The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12365-70. [Content Brief]

[6]. Julie K Monda, et al. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. Structure. 2013 Jan 8;21(1):42-53. [Content Brief]

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