DCN1-like protein 4

Definition:

Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs).

References:

[1]. Matthew J Keuss, et al. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. J Cell Sci. 2016 Apr 1;129(7):1441-54. [Content Brief]

[2]. Julie K Monda, et al. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. Structure. 2013 Jan 8;21(1):42-53. [Content Brief]

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