Death effector domain-containing protein

Definition:

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).

References:

[1]. Justine C Lee, et al. DEDD regulates degradation of intermediate filaments during apoptosis. J Cell Biol. 2002 Sep 16;158(6):1051-66. [Content Brief]

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