Death-inducing signaling complex (DISC)

Definition:

The death-inducing signaling complex (DISC) is a fundamental multiprotein complex, which consists of different death domain (DD) and death effector domain (DED) containing proteins such as the death receptor Fas (CD95) in complex with FADD, procaspase-8, and cFLIP. DISC triggers the extrinsic apoptosis pathway through stimulation by death ligands.

References:

[1]. Sayyed Jalil Mahdizadeh, et al. Reconstruction of the Fas-Based Death-Inducing Signaling Complex (DISC) Using a Protein-Protein Docking Meta-Approach. J Chem Inf Model. 2021 Jul 26;61(7):3543-3558. [Content Brief]

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