Defensin beta 118

Definition:

Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis. Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes. Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface. Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization. May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms.

References:

[1]. Qian Lin, et al. Expression and Functional Characterization of a Novel Antimicrobial Peptide: Human Beta-Defensin 118. Biomed Res Int. 2020 Nov 9;2020:1395304. [Content Brief]

[2]. Jing Hou, et al. The truncated human beta-defensin 118 can modulate lipopolysaccharide mediated inflammatory response in RAW264.7 macrophages. Peptides. 2021 Feb;136:170438. [Content Brief]

[3]. Suresh Yenugu, et al. The androgen-regulated epididymal sperm-binding protein, human beta-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial beta-defensin. Endocrinology. 2004 Jul;145(7):3165-73. [Content Brief]

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