Dentin dysplasia

Definition:

Dentin dysplasia (DD/DTDP) is a rare hereditary disturbance of dentin formation. Dentin dysplasia is divided into two main classes based on the clinical and radiographic appearance, type I (DD1/DTDP1) and type II (DD2/DTDP2). Type 1 is referred to as radicular dentin dysplasia and type 2 as coronal dentin dysplasia.

References:

[1]. Aarti Singh, et al. Dentin dysplasia type I. BMJ Case Rep. 2013 Jun 27;2013:bcr2013009403. [Content Brief]

[2]. M Helen Rajpar, et al. Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization. Hum Mol Genet. 2002 Oct 1;11(21):2559-65. [Content Brief]

[3]. S Alfawaz, et al. Recessive oligodontia linked to a homozygous loss-of-function mutation in the SMOC2 gene. Arch Oral Biol. 2013 May;58(5):462-6. [Content Brief]

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