Deoxyguanosine kinase, mitochondrial

Definition:

Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents.

References:

[1]. L Wang, et al. Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA. FEBS Lett. 1996 Jul 15;390(1):39-43. [Content Brief]

[2]. A Saada, et al. Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. Nat Genet. 2001 Nov;29(3):342-4. [Content Brief]

[3]. M Johansson, et al. Cloning and expression of human deoxyguanosine kinase cDNA. Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7258-62. [Content Brief]

[4]. Dario Ronchi, et al. Next-generation sequencing reveals DGUOK mutations in adult patients with mitochondrial DNA multiple deletions. Brain. 2012 Nov;135(Pt 11):3404-15. [Content Brief]

[5]. Bénédicte Mousson de Camaret, et al. Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion. Biochem J. 2007 Mar 1;402(2):377-85. [Content Brief]

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