Deoxyribonuclease-1-like 2

Definition:

Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells.

References:

[1]. Heinz Fischer, et al. DNase1L2 degrades nuclear DNA during corneocyte formation. J Invest Dermatol. 2007 Jan;127(1):24-30. [Content Brief]

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