Differential Scanning Calorimetry

Definition:

Differential scanning calorimetry (DSC) is a thermoanalytical technique in which the difference in the amount of heat required to increase the temperature of a sample and reference in solution is measured as a function of temperature. By measuring the temperature dependence of this partial heat capacity, a basic thermodynamic property, DSC gives immediate access to the thermodynamic mechanism that governs a conformational equilibrium, for example between a protein complex and its individual participants.

References:

[1]. Ontobee, Molecular Interactions Controlled Vocabulary, MI_1311, Differential Scanning Calorimetry.

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