Dihydroorotate dehydrogenase (DHODH)

Definition:

Dihydroorotate dehydrogenase (DHODH) is the key enzyme in de novo biosynthesis of pyrimidine in both prokaryotes and eukaryotes that provides nucleotides for RNA/DNA synthesis essential for proliferation. DHODH also is rate-limiting enzyme in biosynthesis of pyrimidone which catalyzes the oxidation of dihydro-orotate to orotate. DHODH paly a role in cancer cells proliferation.

References:

[1]. A K Mohamad Fairus, et al. Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells. Biochimie. 2017 Apr;135:154-163. [Content Brief]

[2]. Hardeep Kaur, et al. Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors "leflunomide" and "teriflunomide" in Covid-19: A narrative review. Eur J Pharmacol. 2021 Sep 5;906:174233. [Content Brief]

[3]. Stepana Boukalova, et al. Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165759. [Content Brief]

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