Dihydropyrimidinase-related protein 1

Definition:

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis.

References:

[1]. J Y Shih, et al. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. J Natl Cancer Inst. 2001 Sep 19;93(18):1392-400. [Content Brief]

[2]. Fumio Nakamura, et al. Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling. Nat Commun. 2014 Oct 31;5:5325. [Content Brief]

[3]. Tzu-Chi Chen, et al. From midbody protein-protein interaction network construction to novel regulators in cytokinesis. J Proteome Res. 2009 Nov;8(11):4943-53. [Content Brief]

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