Dipeptidase 1

Definition:

Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Possesses also beta lactamase activity and can hydrolyze the beta-lactam antibiotic imipenem.; Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.

References:

[1]. H Adachi, et al. Primary structure of human microsomal dipeptidase deduced from molecular cloning. J Biol Chem. 1990 Mar 5;265(7):3992-5. [Content Brief]

[2]. B J Campbell, et al. Beta-lactamase activity of purified and partially characterized human renal dipeptidase. J Biol Chem. 1984 Dec 10;259(23):14586-90. [Content Brief]

[3]. Saurav Roy Choudhury, et al. Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver. Cell. 2019 Aug 22;178(5):1205-1221.e17. [Content Brief]

[4]. Kristyn Hayashi, et al. Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity. J Struct Biol. 2020 Jul 1;211(1):107512. [Content Brief]

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