Disorders of innate immunity

Definition:

Innate immune responses represent the first line of defense against potentially invading organisms. Disorders of innate immunity (e.g. phagocyte and complement disorders) delay the induction of the immune response and may worsen outcomes of infection.

References:

[1]. Christine McCusker, et al. Primary immunodeficiency. Allergy Asthma Clin Immunol. 2011 Nov 10;7 Suppl 1(Suppl 1):S11. [Content Brief]

[2]. Christopher J A Duncan, et al. Human IFNAR2 deficiency: Lessons for antiviral immunity. Sci Transl Med. 2015 Sep 30;7(307):307ra154. [Content Brief]

[3]. Delphine Cuchet-Lourenço, et al. Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science. 2018 Aug 24;361(6404):810-813. [Content Brief]

[4]. Emily M Mace, et al. Human NK cell deficiency as a result of biallelic mutations in MCM10. J Clin Invest. 2020 Oct 1;130(10):5272-5286. [Content Brief]

[5]. Ian T Lamborn, et al. Recurrent rhinovirus infections in a child with inherited MDA5 deficiency. J Exp Med. 2017 Jul 3;214(7):1949-1972. [Content Brief]

[6]. Isabel Z Fernandez, et al. A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 Jun 3;216(6):1255-1267. [Content Brief]

[7]. Leidy C Merselis, et al. MPEG1/Perforin-2 Haploinsufficiency Associated Polymicrobial Skin Infections and Considerations for Interferon-γ Therapy. Front Immunol. 2020 Nov 3;11:601584. [Content Brief]

[8]. María Bravo García-Morato, et al. Impaired control of multiple viral infections in a family with complete IRF9 deficiency. J Allergy Clin Immunol. 2019 Jul;144(1):309-312.e10. [Content Brief]

[9]. Sophie Hambleton, et al. STAT2 deficiency and susceptibility to viral illness in humans. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3053-8. [Content Brief]

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