Disruptor of telomeric silencing 1-like (DOT1L)

Definition:

Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase, which catalyzes mmethylation of H3K79me. DOT1L is associated eith chromatin-associated functions, such as gene transcription, heterochromatin formation, and DNA repair.

References:

[1]. Kari V, et al. The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness. Clin Epigenetics. 2019 Jan 7;11(1):4. [Content Brief]

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