DNA repair endonuclease XPF

Definition:

Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair.

References:

[1]. Jiajia Wang, et al. Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation. Nat Commun. 2020 Feb 7;11(1):786. [Content Brief]

[2]. A M Sijbers, et al. Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease. Cell. 1996 Sep 6;86(5):811-22. [Content Brief]

[3]. Jennifer M Svendsen, et al. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell. 2009 Jul 10;138(1):63-77. [Content Brief]

[4]. Ana Osorio, et al. Evaluation of rare variants in the new fanconi anemia gene ERCC4 (FANCQ) as familial breast/ovarian cancer susceptibility alleles. Hum Mutat. 2013 Dec;34(12):1615-8. [Content Brief]

[5]. S L McCutchen-Maloney, et al. Domain mapping of the DNA binding, endonuclease, and ERCC1 binding properties of the human DNA repair protein XPF. Biochemistry. 1999 Jul 20;38(29):9417-25. [Content Brief]

[6]. Kandallu R Kumaresan, et al. Contribution of XPF functional domains to the 5' and 3' incisions produced at the site of a psoralen interstrand cross-link. Biochemistry. 2002 Jan 22;41(3):890-6. [Content Brief]

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