DnaJ homolog subfamily C member 21

Definition:

May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA.

References:

[1]. Hemanth Tummala, et al. DNAJC21 Mutations Link a Cancer-Prone Bone Marrow Failure Syndrome to Corruption in 60S Ribosome Subunit Maturation. Am J Hum Genet. 2016 Jul 7;99(1):115-24. [Content Brief]

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